Research

Aging research have accumulated many genes and pathways that are implicated in the aging process, but much rarer are knowledge about how they work together as a system. Our research has shown that the aging processes are dynamically and mathematically similar in many organisms as distinct as bacteria and human. Having a computable, mathematical model enabled us to answer both fundamental and applied questions when it comes to aging and longevity. Our recent publications has dealth with questions such as why individuals die at different age, or how to compress age-related morbidities.

All

2025

A damage accumulation model reveals strategies of aging across species

[no publisher info]  ·  08 Jul 2025  ·  doi:10.21203/rs.3.rs-6946440/v1

Dynamic growth trajectories distinguish bacteriostatic and bactericidal antibiotics at subinhibitory concentrations

E. Vaisbourd, D. S. Glass, Y. Yang, A. Mayo, A. Bren, U. Alon

[no publisher info]  ·  19 Jun 2025  ·  doi:10.1101/2025.06.14.659040

Compression of morbidity by interventions that steepen the survival curve

Yifan Yang, Avi Mayo, Tomer Levy, Naveh Raz, Ben Shenhar, Daniel F. Jarosz, Uri Alon

Nature Communications  ·  08 Apr 2025  ·  doi:10.1038/s41467-025-57807-5

2023

Compression of morbidity by interventions that steepen the survival curve

Yifan Yang, Avi Mayo, Tomer Levy, Naveh Raz, Dan Jarosz, Uri Alon

Cold Spring Harbor Laboratory  ·  05 Oct 2023  ·  doi:10.1101/2023.10.04.560871

Damage dynamics and the role of chance in the timing of E. coli cell death

Yifan Yang, Omer Karin, Avi Mayo, Xiaohu Song, Peipei Chen, Ana L. Santos, Ariel B. Lindner, Uri Alon

Nature Communications  ·  18 Apr 2023  ·  doi:10.1038/s41467-023-37930-x

2022

Damage dynamics in singleE. coliand the role of chance in the timing of cell death

Yifan Yang, Omer Karin, Avi Mayo, Alon Bar, Xiaohu Song, Peipei Chen, Ana L. Santos, Ariel B. Lindner, Uri Alon

Cold Spring Harbor Laboratory  ·  17 Oct 2022  ·  doi:10.1101/2022.10.17.512406

2019

Temporal scaling of aging as an adaptive strategy of Escherichia coli

Yifan Yang, Ana L. Santos, Luping Xu, Chantal Lotton, François Taddei, Ariel B. Lindner

Science Advances  ·  03 May 2019  ·  doi:10.1126/sciadv.aaw2069

2018

Temporal scaling of ageing as an adaptive strategy ofEscherichia coli

Yifan Yang, Ana L. Santos, Luping Xu, Chantal Lotton, François Taddei, Ariel B. Lindner

Cold Spring Harbor Laboratory  ·  24 Jul 2018  ·  doi:10.1101/376566

2016

Time-lapse microscopy and image analysis of Escherichia coli cells in mother machines

Y. Yang, X. Song, A.B. Lindner

Methods in Microbiology  ·  01 Jan 2016  ·  doi:10.1016/bs.mim.2016.10.003

2015

A synthetic growth switch based on controlled expression of RNA polymerase

Jérôme Izard, Cindy DC Gomez Balderas, Delphine Ropers, Stephan Lacour, Xiaohu Song, Yifan Yang, Ariel B Lindner, Johannes Geiselmann, Hidde de Jong

Molecular Systems Biology  ·  01 Nov 2015  ·  doi:10.15252/msb.20156382

2007

ProTISA: a comprehensive resource for translation initiation site annotation in prokaryotic genomes

G.-Q. Hu, X. Zheng, Y.-F. Yang, P. Ortet, Z.-S. She, H. Zhu

Nucleic Acids Research  ·  23 Dec 2007  ·  doi:10.1093/nar/gkm799

MED: a new non-supervised gene prediction algorithm for bacterial and archaeal genomes

Huaiqiu Zhu, Gang-Qing Hu, Yi-Fan Yang, Jin Wang, Zhen-Su She

BMC Bioinformatics  ·  16 Mar 2007  ·  doi:10.1186/1471-2105-8-97